Motif ID: TFAP2{A,C}.p2

Z-value: 2.733


Transcription factors associated with TFAP2{A,C}.p2:

Gene SymbolEntrez IDGene Name
TFAP2A 7020 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C 7022 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Achr6_-_105232030.581.9e-02Click!
TFAP2Cchr20_+_546377140.263.4e-01Click!


Activity profile for motif TFAP2{A,C}.p2.

activity profile for motif TFAP2{A,C}.p2


Sorted Z-values histogram for motif TFAP2{A,C}.p2

Sorted Z-values for motif TFAP2{A,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2{A,C}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_104394185 6.114 NM_030912
TRIM8
tripartite motif containing 8
chr2_+_236068029 4.040 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr2_+_96845704 3.182 NM_017623
NM_199078
CNNM3

cyclin M3

chr19_+_540849 2.898 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr20_+_254205 2.785 NM_006943
SOX12
SRY (sex determining region Y)-box 12
chr2_+_236067687 2.670 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr20_+_2031418 2.659 STK35
serine/threonine kinase 35
chr7_+_150414704 2.569 NM_001042535
NM_031946
AGAP3

ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

chr1_+_2149993 2.531 NM_003036
SKI
v-ski sarcoma viral oncogene homolog (avian)
chr20_+_34635362 2.529 NM_021809
TGIF2
TGFB-induced factor homeobox 2
chr6_+_157141565 2.465 ARID1B
AT rich interactive domain 1B (SWI1-like)
chr20_-_30636535 2.404 LOC284804
hypothetical protein LOC284804
chr17_+_72376022 2.379 NM_144677
MGAT5B
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chr9_+_128416542 2.211 NM_001174146
NM_001174147
NM_002316
LMX1B


LIM homeobox transcription factor 1, beta


chr10_+_80672842 2.166 ZMIZ1
zinc finger, MIZ-type containing 1
chr19_+_1200882 2.164 MIDN
midnolin
chr3_+_38470782 2.163 NM_001106
ACVR2B
activin A receptor, type IIB
chr20_-_2031521 2.149


chr16_-_87535106 2.112 NM_175931
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr3_+_51403760 2.101 NM_013286
RBM15B
RNA binding motif protein 15B
chr7_+_150442652 2.095 AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr9_+_136673534 2.063 COL5A1
collagen, type V, alpha 1
chr12_+_131577229 2.051 NM_001142641
FBRSL1
fibrosin-like 1
chr17_+_17525571 2.019


chr15_+_64782468 2.005 SMAD6
SMAD family member 6
chr16_+_88517187 1.977 NM_006086
TUBB3
tubulin, beta 3
chr2_+_236067424 1.932 NM_001037131
NM_014914
AGAP1

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

chr20_+_60906605 1.898 NM_007346
OGFR
opioid growth factor receptor
chr9_+_136358145 1.803 RXRA
retinoid X receptor, alpha
chr6_+_37895570 1.786 ZFAND3
zinc finger, AN1-type domain 3
chrX_+_153339814 1.737 NM_017514
PLXNA3
plexin A3
chr17_+_17525497 1.729 NM_030665
RAI1
retinoic acid induced 1
chr5_+_139008667 1.721 CXXC5
CXXC finger protein 5
chr2_+_241023908 1.701 GPC1
glypican 1
chr8_+_81560971 1.699 NM_001105539
NM_023929
ZBTB10

zinc finger and BTB domain containing 10

chr16_+_87047418 1.699 NM_153813
ZFPM1
zinc finger protein, multitype 1
chr22_+_48740432 1.691 PIM3
pim-3 oncogene
chr16_+_49139694 1.613 NM_033119
NKD1
naked cuticle homolog 1 (Drosophila)
chr15_+_94674849 1.612 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr3_+_50217692 1.597 NM_006841
SLC38A3
solute carrier family 38, member 3
chr5_+_179180695 1.593 SQSTM1
sequestosome 1
chr10_+_80498782 1.547 NM_020338
ZMIZ1
zinc finger, MIZ-type containing 1
chr5_+_179180509 1.537 SQSTM1
sequestosome 1
chr16_+_83291112 1.537 USP10
ubiquitin specific peptidase 10
chr8_+_37672427 1.534 NM_025069
ZNF703
zinc finger protein 703
chr19_+_63747829 1.510 TRIM28
tripartite motif containing 28
chr6_+_37895244 1.506 NM_021943
ZFAND3
zinc finger, AN1-type domain 3
chr1_+_33494745 1.502 NM_152493
ZNF362
zinc finger protein 362
chr19_+_10689813 1.499 DNM2
dynamin 2
chr20_-_34635091 1.480


chr9_+_95378492 1.459 NM_005392
PHF2
PHD finger protein 2
chr17_+_45993338 1.457 NM_018896
NM_198376
NM_198377
NM_198378
NM_198379
NM_198380
NM_198382
NM_198383
NM_198384
NM_198385
NM_198386
NM_198387
NM_198388
NM_198396
NM_198397
CACNA1G














calcium channel, voltage-dependent, T type, alpha 1G subunit














chr6_+_157140954 1.448 ARID1B
AT rich interactive domain 1B (SWI1-like)
chr20_+_4077466 1.442 SMOX
spermine oxidase
chr9_+_115958051 1.435 NM_032888
COL27A1
collagen, type XXVII, alpha 1
chr19_+_40183169 1.432 GRAMD1A
GRAM domain containing 1A
chr2_+_120820140 1.422 NM_002193
INHBB
inhibin, beta B
chr6_+_43846155 1.398 VEGFA
vascular endothelial growth factor A
chr1_+_226337052 1.390 ARF1
ADP-ribosylation factor 1
chr11_+_67836575 1.386 NM_002335
LRP5
low density lipoprotein receptor-related protein 5
chr9_+_136358134 1.382 NM_002957
RXRA
retinoid X receptor, alpha
chr20_+_30019465 1.375 NM_001011718
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr2_+_241023880 1.372


chr5_+_179180517 1.371 SQSTM1
sequestosome 1
chr20_+_2030527 1.364 NM_080836
STK35
serine/threonine kinase 35
chr9_+_136673464 1.360 NM_000093
COL5A1
collagen, type V, alpha 1
chr17_+_75366524 1.346 NM_005189
NM_032647
CBX2

chromobox homolog 2

chr19_+_1199548 1.341 NM_177401
MIDN
midnolin
chr15_+_65145215 1.337 SMAD3
SMAD family member 3
chr16_+_73590739 1.328 ZNRF1
zinc and ring finger 1
chr2_+_241586927 1.320 NM_001080437
SNED1
sushi, nidogen and EGF-like domains 1
chr5_+_149845503 1.318 NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr20_+_55399847 1.299 NM_017495
NM_183425
RBM38

RNA binding motif protein 38

chr17_-_6400470 1.296 NM_001165966
NM_031220
PITPNM3

PITPNM family member 3

chr17_+_7152417 1.295 NM_001143762
EIF5A
eukaryotic translation initiation factor 5A
chr22_+_43476710 1.286 NM_181333
PRR5
proline rich 5 (renal)
chr10_-_134449467 1.268 NM_177400
NKX6-2
NK6 homeobox 2
chr1_+_24944554 1.266 CLIC4
chloride intracellular channel 4
chr2_+_231610438 1.265 NM_001144994
C2orf72
chromosome 2 open reading frame 72
chr19_+_1358750 1.255 DAZAP1
DAZ associated protein 1
chr17_+_45778381 1.248 NM_022167
XYLT2
xylosyltransferase II
chr17_+_52026058 1.234 NM_005450
NOG
noggin
chr19_+_8415869 1.229 HNRNPM
heterogeneous nuclear ribonucleoprotein M
chr20_+_33667160 1.226 NM_003116
SPAG4
sperm associated antigen 4
chr9_+_115957537 1.215 COL27A1
collagen, type XXVII, alpha 1
chr17_+_53515725 1.212 NM_080677
DYNLL2
dynein, light chain, LC8-type 2
chr19_+_8415875 1.204 HNRNPM
heterogeneous nuclear ribonucleoprotein M
chr10_-_76829857 1.202 ZNF503
zinc finger protein 503
chr19_+_13090101 1.202 NM_052876
NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr5_+_92946348 1.201 NR2F1
nuclear receptor subfamily 2, group F, member 1
chr10_+_134201262 1.199 NM_005539
INPP5A
inositol polyphosphate-5-phosphatase, 40kDa
chr19_-_60587414 1.184 NM_001190764
LOC388564
hypothetical protein LOC388564
chr18_+_53253775 1.184 NM_004852
ONECUT2
one cut homeobox 2
chr16_+_73590375 1.181 NM_032268
ZNRF1
zinc and ring finger 1
chr6_+_157140895 1.163


chr16_+_83291097 1.163 USP10
ubiquitin specific peptidase 10
chr7_+_129038765 1.157 NM_005011
NRF1
nuclear respiratory factor 1
chr17_+_24944605 1.156 NM_152345
ANKRD13B
ankyrin repeat domain 13B
chr21_+_44109529 1.152 NM_020132
AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr20_-_33343617 1.150 NM_178468
FAM83C
family with sequence similarity 83, member C
chr16_+_87047159 1.143 ZFPM1
zinc finger protein, multitype 1
chr20_+_60810610 1.140 NM_002531
NTSR1
neurotensin receptor 1 (high affinity)
chr16_+_83291055 1.127 NM_005153
USP10
ubiquitin specific peptidase 10
chr20_+_2621193 1.123 NM_001110514
EBF4
early B-cell factor 4
chr3_-_197120276 1.123 NM_005781
TNK2
tyrosine kinase, non-receptor, 2
chr5_-_172594691 1.123 NM_001166175
NM_001166176
NM_004387
NKX2-5


NK2 transcription factor related, locus 5 (Drosophila)


chr3_+_50167851 1.120 NM_004186
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr19_+_39664706 1.119 NM_001080436
WTIP
Wilms tumor 1 interacting protein
chr20_+_56899904 1.119 GNAS
GNAS complex locus
chr10_+_98582648 1.106 NM_032440
LCOR
ligand dependent nuclear receptor corepressor
chr20_-_55274497 1.100 BMP7
bone morphogenetic protein 7
chr2_-_47650973 1.095 NM_022055
KCNK12
potassium channel, subfamily K, member 12
chr22_+_18091065 1.088 NM_000407
GP1BB
glycoprotein Ib (platelet), beta polypeptide
chr2_+_238540411 1.085 UBE2F
ubiquitin-conjugating enzyme E2F (putative)
chr3_+_185515543 1.084 NM_182917
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr12_-_120715937 1.083 NM_019034
RHOF
ras homolog gene family, member F (in filopodia)
chr4_+_3434830 1.076 NM_001164673
NM_173660
DOK7

docking protein 7

chr5_+_179180447 1.066 NM_003900
SQSTM1
sequestosome 1
chr1_+_226336983 1.058 NM_001024226
NM_001658
ARF1

ADP-ribosylation factor 1

chr15_+_72861767 1.053 CSK
c-src tyrosine kinase
chr19_+_3958690 1.053 NM_015897
PIAS4
protein inhibitor of activated STAT, 4
chr22_+_43476755 1.052 NM_181334
PRR5-ARHGAP8
PRR5
PRR5-ARHGAP8 readthrough
proline rich 5 (renal)
chr2_+_241023703 1.046 NM_002081
GPC1
glypican 1
chr20_+_226200 1.040 NM_033089
ZCCHC3
zinc finger, CCHC domain containing 3
chr17_+_43480723 1.035 NFE2L1
nuclear factor (erythroid-derived 2)-like 1
chr16_+_73590419 1.031 ZNRF1
zinc and ring finger 1
chr1_+_226337016 1.031 ARF1
ADP-ribosylation factor 1
chr2_+_36436316 1.029 CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr21_+_44109454 1.026 AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr18_+_18969724 1.021 NM_001100619
CABLES1
Cdk5 and Abl enzyme substrate 1
chr17_+_43480724 1.021 NFE2L1
nuclear factor (erythroid-derived 2)-like 1
chr15_+_72861470 1.019 NM_001127190
NM_004383
CSK

c-src tyrosine kinase

chr16_+_73590470 1.018 ZNRF1
zinc and ring finger 1
chr19_-_1799447 1.018 NM_020695
REXO1
REX1, RNA exonuclease 1 homolog (S. cerevisiae)
chr2_+_36436873 1.017 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr19_+_18803786 1.014 UPF1
UPF1 regulator of nonsense transcripts homolog (yeast)
chr17_-_76064842 1.012 NM_002522
NPTX1
neuronal pentraxin I
chr22_+_36531246 1.008 H1F0
H1 histone family, member 0
chr16_+_85158357 1.008 NM_005251
FOXC2
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr6_+_43846372 1.007 VEGFA
vascular endothelial growth factor A
chr1_+_9571518 1.005 NM_001010866
NM_001130924
TMEM201

transmembrane protein 201

chr5_+_36912656 1.004 NIPBL
Nipped-B homolog (Drosophila)
chr16_-_695719 1.003 NM_153350
FBXL16
F-box and leucine-rich repeat protein 16
chr16_+_83291107 1.002 USP10
ubiquitin specific peptidase 10
chr2_+_171280944 0.984 SP5
Sp5 transcription factor
chr16_+_88154638 0.983 RPL13
ribosomal protein L13
chr17_+_43480674 0.982 NM_003204
NFE2L1
nuclear factor (erythroid-derived 2)-like 1
chr19_+_8415802 0.981 NM_005968
NM_031203
HNRNPM

heterogeneous nuclear ribonucleoprotein M

chr7_+_39956633 0.980 CDK13
cyclin-dependent kinase 13
chr19_+_63747678 0.979 TRIM28
tripartite motif containing 28
chr19_+_3136965 0.973 NCLN
nicalin
chr10_+_134060681 0.972 NM_001098637
NM_138499
PWWP2B

PWWP domain containing 2B

chr12_+_119456538 0.972 RNF10
ring finger protein 10
chr16_+_24648446 0.971 NM_014494
TNRC6A
trinucleotide repeat containing 6A
chr20_-_55275078 0.969 NM_001719
BMP7
bone morphogenetic protein 7
chr10_+_82204046 0.969 TSPAN14
tetraspanin 14
chr15_+_65145248 0.966 NM_005902
SMAD3
SMAD family member 3
chr6_+_43846735 0.963 VEGFA
vascular endothelial growth factor A
chr17_+_77780177 0.963 NM_004207
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr19_+_3136927 0.963 NCLN
nicalin
chr10_+_82204051 0.961 TSPAN14
tetraspanin 14
chr4_-_7039661 0.956 LOC100134937
hypothetical LOC100134937
chr19_+_3045528 0.955 GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
chr1_+_224317062 0.953 H3F3A
LOC440926
H3 histone, family 3A
H3 histone, family 3A pseudogene
chr14_+_23633101 0.953 NM_001018073
NM_004563
PCK2

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

chr5_+_139008091 0.953 CXXC5
CXXC finger protein 5
chr17_+_34140030 0.949 NM_001136498
CISD3
CDGSH iron sulfur domain 3
chr2_+_238540428 0.948 NM_080678
UBE2F
ubiquitin-conjugating enzyme E2F (putative)
chr10_-_32676090 0.947 NM_025209
EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr6_+_1556543 0.946 FOXC1
forkhead box C1
chr17_+_38186141 0.939 NM_032387
WNK4
WNK lysine deficient protein kinase 4
chr10_+_82204054 0.939 TSPAN14
tetraspanin 14
chrX_+_152606945 0.937 NM_001142805
NM_005629
SLC6A8

solute carrier family 6 (neurotransmitter transporter, creatine), member 8

chr9_+_134026836 0.935 NTNG2
netrin G2
chr16_+_84204424 0.933 NM_014615
KIAA0182
KIAA0182
chr4_+_110574274 0.931 SEC24B
SEC24 family, member B (S. cerevisiae)
chr19_+_10689772 0.928 DNM2
dynamin 2
chr16_+_3447957 0.927 NM_001083600
NM_024845
NAT15

N-acetyltransferase 15 (GCN5-related, putative)

chr19_+_7566698 0.926 NM_001080429
NM_020902
KIAA1543

KIAA1543

chr14_+_104226769 0.922 NM_001031714
NM_022489
NM_032714
INF2


inverted formin, FH2 and WH2 domain containing


chr19_+_63747638 0.922 NM_005762
TRIM28
tripartite motif containing 28
chr7_+_4688248 0.919 NM_001037165
FOXK1
forkhead box K1
chr16_+_15950707 0.916 NM_004996
NM_019862
NM_019898
NM_019899
NM_019900
ABCC1




ATP-binding cassette, sub-family C (CFTR/MRP), member 1




chr1_+_51474583 0.915 RNF11
ring finger protein 11
chr19_+_2220529 0.914 OAZ1
ornithine decarboxylase antizyme 1
chr8_+_142471290 0.912


chr16_+_28741861 0.912 ATXN2L
ataxin 2-like
chr19_+_482737 0.911 CDC34
cell division cycle 34 homolog (S. cerevisiae)
chr19_+_10689763 0.909 DNM2
dynamin 2
chr20_+_29656744 0.907 NM_002165
NM_181353
ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

chr1_+_24944493 0.904 CLIC4
chloride intracellular channel 4
chr1_-_25129305 0.903 RUNX3
runt-related transcription factor 3
chr6_+_37245860 0.902 NM_002648
PIM1
pim-1 oncogene
chr6_+_43247179 0.900 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr19_+_2115119 0.899 NM_032482
DOT1L
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
chr7_+_288051 0.899 NM_020223
FAM20C
family with sequence similarity 20, member C
chr19_+_2220526 0.898 OAZ1
ornithine decarboxylase antizyme 1
chr7_-_129038701 0.897


chr17_+_72880967 0.897 SEPT9
septin 9
chr19_+_4920126 0.896 KDM4B
lysine (K)-specific demethylase 4B

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.08 9.74e-22 GO:0009987 cellular process
1.15 3.79e-15 GO:0044260 cellular macromolecule metabolic process
1.11 1.71e-14 GO:0044237 cellular metabolic process
1.12 3.20e-11 GO:0043170 macromolecule metabolic process
1.09 5.63e-11 GO:0008152 metabolic process
1.15 1.32e-09 GO:0016043 cellular component organization
1.09 1.40e-09 GO:0044238 primary metabolic process
1.09 1.41e-09 GO:0050794 regulation of cellular process
1.08 5.08e-09 GO:0065007 biological regulation
1.08 5.29e-09 GO:0050789 regulation of biological process
1.13 3.80e-08 GO:0071840 cellular component organization or biogenesis
1.16 3.87e-08 GO:0071842 cellular component organization at cellular level
1.16 4.42e-08 GO:0044267 cellular protein metabolic process
1.16 4.83e-08 GO:0048522 positive regulation of cellular process
1.13 2.34e-07 GO:0031323 regulation of cellular metabolic process
1.18 3.02e-07 GO:0043412 macromolecule modification
1.13 3.57e-07 GO:0007275 multicellular organismal development
1.15 7.23e-07 GO:0048518 positive regulation of biological process
1.14 8.28e-07 GO:0071841 cellular component organization or biogenesis at cellular level
1.18 8.69e-07 GO:0006464 protein modification process
1.21 9.55e-07 GO:0009966 regulation of signal transduction
1.19 1.32e-06 GO:0023051 regulation of signaling
1.12 1.38e-06 GO:0032502 developmental process
1.20 1.65e-06 GO:0007399 nervous system development
1.11 2.26e-06 GO:0019222 regulation of metabolic process
1.12 2.92e-06 GO:0080090 regulation of primary metabolic process
1.16 3.01e-06 GO:0048523 negative regulation of cellular process
1.14 4.13e-06 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.18 6.11e-06 GO:0006996 organelle organization
1.29 6.60e-06 GO:0009790 embryo development
1.13 9.60e-06 GO:0048731 system development
1.14 2.35e-05 GO:0048519 negative regulation of biological process
1.23 2.65e-05 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.12 2.88e-05 GO:0048856 anatomical structure development
1.12 3.04e-05 GO:0006807 nitrogen compound metabolic process
1.12 3.10e-05 GO:0060255 regulation of macromolecule metabolic process
1.12 3.87e-05 GO:0034641 cellular nitrogen compound metabolic process
1.14 5.58e-05 GO:0044249 cellular biosynthetic process
1.14 5.90e-05 GO:0090304 nucleic acid metabolic process
1.18 6.84e-05 GO:0009653 anatomical structure morphogenesis
1.42 9.46e-05 GO:0035295 tube development
1.13 1.40e-04 GO:0009058 biosynthetic process
1.12 1.64e-04 GO:0019538 protein metabolic process
1.20 1.79e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.35 2.18e-04 GO:0009792 embryo development ending in birth or egg hatching
1.35 2.26e-04 GO:0043009 chordate embryonic development
1.16 2.95e-04 GO:0034645 cellular macromolecule biosynthetic process
1.29 3.28e-04 GO:0051253 negative regulation of RNA metabolic process
1.27 3.74e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.25 4.49e-04 GO:0045595 regulation of cell differentiation
1.16 5.33e-04 GO:0009059 macromolecule biosynthetic process
1.26 6.77e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
1.40 7.99e-04 GO:0045596 negative regulation of cell differentiation
1.12 8.61e-04 GO:0051171 regulation of nitrogen compound metabolic process
1.15 9.39e-04 GO:0010467 gene expression
1.26 1.01e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.28 1.02e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.25 1.05e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.21 1.39e-03 GO:0010605 negative regulation of macromolecule metabolic process
1.18 1.55e-03 GO:0009893 positive regulation of metabolic process
1.12 1.82e-03 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.12 1.87e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.29 1.87e-03 GO:0048646 anatomical structure formation involved in morphogenesis
1.10 2.05e-03 GO:0051179 localization
1.26 2.15e-03 GO:0009887 organ morphogenesis
1.21 2.28e-03 GO:0006351 transcription, DNA-dependent
1.31 2.35e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.20 3.42e-03 GO:0031324 negative regulation of cellular metabolic process
1.28 3.49e-03 GO:0072358 cardiovascular system development
1.28 3.49e-03 GO:0072359 circulatory system development
1.12 4.56e-03 GO:0051252 regulation of RNA metabolic process
1.14 4.76e-03 GO:0048583 regulation of response to stimulus
1.23 4.79e-03 GO:0009890 negative regulation of biosynthetic process
1.23 4.81e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.34 4.86e-03 GO:0051093 negative regulation of developmental process
1.17 5.11e-03 GO:0031325 positive regulation of cellular metabolic process
1.21 5.22e-03 GO:0033554 cellular response to stress
1.30 5.73e-03 GO:0007264 small GTPase mediated signal transduction
1.11 5.76e-03 GO:0010468 regulation of gene expression
1.48 5.99e-03 GO:0060562 epithelial tube morphogenesis
1.35 6.05e-03 GO:0048729 tissue morphogenesis
1.20 6.99e-03 GO:0022008 neurogenesis
1.24 7.09e-03 GO:0051276 chromosome organization
1.31 7.38e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.24 7.76e-03 GO:0010629 negative regulation of gene expression
1.11 7.94e-03 GO:0010556 regulation of macromolecule biosynthetic process
1.19 8.19e-03 GO:0050793 regulation of developmental process
1.14 8.27e-03 GO:0016070 RNA metabolic process
1.19 9.43e-03 GO:0032774 RNA biosynthetic process
1.35 9.55e-03 GO:0032446 protein modification by small protein conjugation
1.16 1.30e-02 GO:0051641 cellular localization
1.12 1.41e-02 GO:0006355 regulation of transcription, DNA-dependent
1.45 1.46e-02 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
1.38 1.87e-02 GO:0002009 morphogenesis of an epithelium
1.22 2.04e-02 GO:0010628 positive regulation of gene expression
1.35 2.06e-02 GO:0016567 protein ubiquitination
1.41 2.18e-02 GO:0035239 tube morphogenesis
1.18 2.50e-02 GO:0009892 negative regulation of metabolic process
1.20 3.01e-02 GO:2000026 regulation of multicellular organismal development
1.29 3.34e-02 GO:0048598 embryonic morphogenesis
1.15 3.68e-02 GO:0033036 macromolecule localization
1.12 3.84e-02 GO:0048869 cellular developmental process
1.17 3.88e-02 GO:0007049 cell cycle
1.28 4.35e-02 GO:0016568 chromatin modification
1.35 4.51e-02 GO:0007507 heart development
1.10 4.58e-02 GO:0031326 regulation of cellular biosynthetic process
1.21 4.83e-02 GO:0051254 positive regulation of RNA metabolic process
1.24 4.97e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.08 3.05e-30 GO:0044424 intracellular part
1.08 7.11e-30 GO:0005622 intracellular
1.11 9.68e-27 GO:0043227 membrane-bounded organelle
1.11 4.34e-26 GO:0043231 intracellular membrane-bounded organelle
1.09 2.70e-25 GO:0043226 organelle
1.09 1.24e-24 GO:0043229 intracellular organelle
1.10 3.58e-19 GO:0005737 cytoplasm
1.12 1.10e-15 GO:0044446 intracellular organelle part
1.12 2.10e-15 GO:0044422 organelle part
1.12 2.92e-15 GO:0005634 nucleus
1.11 4.27e-15 GO:0044444 cytoplasmic part
1.18 2.25e-09 GO:0044428 nuclear part
1.18 2.55e-09 GO:0005829 cytosol
1.18 6.20e-08 GO:0031981 nuclear lumen
1.15 5.87e-07 GO:0070013 intracellular organelle lumen
1.15 8.96e-07 GO:0031090 organelle membrane
1.20 9.72e-07 GO:0005654 nucleoplasm
1.14 2.14e-06 GO:0043233 organelle lumen
1.14 4.16e-06 GO:0031974 membrane-enclosed lumen
1.02 6.75e-06 GO:0005623 cell
1.02 7.93e-06 GO:0044464 cell part
1.21 3.26e-05 GO:0005794 Golgi apparatus
1.16 6.46e-05 GO:0012505 endomembrane system
1.26 1.23e-04 GO:0044431 Golgi apparatus part
1.27 5.54e-04 GO:0000139 Golgi membrane
1.25 9.23e-04 GO:0005694 chromosome
1.22 1.07e-03 GO:0044451 nucleoplasm part
1.26 1.75e-03 GO:0044427 chromosomal part
1.09 2.83e-03 GO:0032991 macromolecular complex
1.09 1.00e-02 GO:0043234 protein complex
1.32 3.30e-02 GO:0000785 chromatin
1.39 3.83e-02 GO:0005912 adherens junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 1.90e-22 GO:0005515 protein binding
1.06 1.76e-18 GO:0005488 binding
1.13 2.48e-07 GO:0003676 nucleic acid binding
1.23 9.84e-07 GO:0030528 transcription regulator activity
1.14 2.91e-06 GO:0003677 DNA binding
1.24 2.71e-04 GO:0043565 sequence-specific DNA binding
1.07 4.98e-04 GO:0003824 catalytic activity
1.19 5.98e-04 GO:0001071 nucleic acid binding transcription factor activity
1.19 5.98e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.14 8.96e-04 GO:0016740 transferase activity
1.28 1.80e-03 GO:0019904 protein domain specific binding
1.34 2.05e-03 GO:0008134 transcription factor binding
1.32 3.78e-03 GO:0016563 transcription activator activity
1.35 1.24e-02 GO:0046982 protein heterodimerization activity
1.24 1.62e-02 GO:0030695 GTPase regulator activity
1.23 3.11e-02 GO:0060589 nucleoside-triphosphatase regulator activity
1.31 3.47e-02 GO:0016881 acid-amino acid ligase activity
1.11 4.55e-02 GO:0008270 zinc ion binding