Motif ID: TFAP2{A,C}.p2

Z-value: 2.733


Transcription factors associated with TFAP2{A,C}.p2:

Gene SymbolEntrez IDGene Name
TFAP2A 7020 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C 7022 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Achr6_-_105232030.581.9e-02Click!
TFAP2Cchr20_+_546377140.263.4e-01Click!


Activity profile for motif TFAP2{A,C}.p2.

activity profile for motif TFAP2{A,C}.p2


Sorted Z-values histogram for motif TFAP2{A,C}.p2

Sorted Z-values for motif TFAP2{A,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2{A,C}.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_104394185 6.114 NM_030912
 TRIM8
tripartite motif containing 8
chr2_+_236068029 4.040 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr2_+_96845704 3.182 NM_017623
NM_199078
 CNNM3

cyclin M3

chr19_+_540849 2.898 NM_001194
 HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr20_+_254205 2.785 NM_006943
 SOX12
SRY (sex determining region Y)-box 12
chr2_+_236067687 2.670 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr20_+_2031418 2.659 STK35
serine/threonine kinase 35
chr7_+_150414704 2.569 NM_001042535
NM_031946
 AGAP3

ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

chr1_+_2149993 2.531 NM_003036
 SKI
v-ski sarcoma viral oncogene homolog (avian)
chr20_+_34635362 2.529 NM_021809
 TGIF2
TGFB-induced factor homeobox 2
chr6_+_157141565 2.465 ARID1B
AT rich interactive domain 1B (SWI1-like)
chr20_-_30636535 2.404 LOC284804
hypothetical protein LOC284804
chr17_+_72376022 2.379 NM_144677
 MGAT5B
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chr9_+_128416542 2.211 NM_001174146
NM_001174147
NM_002316
 LMX1B


LIM homeobox transcription factor 1, beta


chr10_+_80672842 2.166 ZMIZ1
zinc finger, MIZ-type containing 1
chr19_+_1200882 2.164 MIDN
midnolin
chr3_+_38470782 2.163 NM_001106
 ACVR2B
activin A receptor, type IIB
chr20_-_2031521 2.149


chr16_-_87535106 2.112 NM_175931
 CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr3_+_51403760 2.101 NM_013286
 RBM15B
RNA binding motif protein 15B

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 108 entries
enrichment   p-value GO term description
1.48 5.99e-03 GO:0060562 epithelial tube morphogenesis
1.45 1.46e-02 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
1.42 9.46e-05 GO:0035295 tube development
1.41 2.18e-02 GO:0035239 tube morphogenesis
1.40 7.99e-04 GO:0045596 negative regulation of cell differentiation
1.38 1.87e-02 GO:0002009 morphogenesis of an epithelium
1.35 2.18e-04 GO:0009792 embryo development ending in birth or egg hatching
1.35 2.26e-04 GO:0043009 chordate embryonic development
1.35 6.05e-03 GO:0048729 tissue morphogenesis
1.35 9.55e-03 GO:0032446 protein modification by small protein conjugation
1.35 2.06e-02 GO:0016567 protein ubiquitination
1.35 4.51e-02 GO:0007507 heart development
1.34 4.86e-03 GO:0051093 negative regulation of developmental process
1.31 2.35e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.31 7.38e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.30 5.73e-03 GO:0007264 small GTPase mediated signal transduction
1.29 6.60e-06 GO:0009790 embryo development
1.29 3.28e-04 GO:0051253 negative regulation of RNA metabolic process
1.29 1.87e-03 GO:0048646 anatomical structure formation involved in morphogenesis
1.29 3.34e-02 GO:0048598 embryonic morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 32 entries
enrichment   p-value GO term description
1.39 3.83e-02 GO:0005912 adherens junction
1.32 3.30e-02 GO:0000785 chromatin
1.27 5.54e-04 GO:0000139 Golgi membrane
1.26 1.23e-04 GO:0044431 Golgi apparatus part
1.26 1.75e-03 GO:0044427 chromosomal part
1.25 9.23e-04 GO:0005694 chromosome
1.22 1.07e-03 GO:0044451 nucleoplasm part
1.21 3.26e-05 GO:0005794 Golgi apparatus
1.20 9.72e-07 GO:0005654 nucleoplasm
1.18 2.25e-09 GO:0044428 nuclear part
1.18 2.55e-09 GO:0005829 cytosol
1.18 6.20e-08 GO:0031981 nuclear lumen
1.16 6.46e-05 GO:0012505 endomembrane system
1.15 5.87e-07 GO:0070013 intracellular organelle lumen
1.15 8.96e-07 GO:0031090 organelle membrane
1.14 2.14e-06 GO:0043233 organelle lumen
1.14 4.16e-06 GO:0031974 membrane-enclosed lumen
1.12 1.10e-15 GO:0044446 intracellular organelle part
1.12 2.10e-15 GO:0044422 organelle part
1.12 2.92e-15 GO:0005634 nucleus

Gene overrepresentation in function category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
1.35 1.24e-02 GO:0046982 protein heterodimerization activity
1.34 2.05e-03 GO:0008134 transcription factor binding
1.32 3.78e-03 GO:0016563 transcription activator activity
1.31 3.47e-02 GO:0016881 acid-amino acid ligase activity
1.28 1.80e-03 GO:0019904 protein domain specific binding
1.24 2.71e-04 GO:0043565 sequence-specific DNA binding
1.24 1.62e-02 GO:0030695 GTPase regulator activity
1.23 9.84e-07 GO:0030528 transcription regulator activity
1.23 3.11e-02 GO:0060589 nucleoside-triphosphatase regulator activity
1.19 5.98e-04 GO:0001071 nucleic acid binding transcription factor activity
1.19 5.98e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.14 2.91e-06 GO:0003677 DNA binding
1.14 8.96e-04 GO:0016740 transferase activity
1.13 2.48e-07 GO:0003676 nucleic acid binding
1.12 1.90e-22 GO:0005515 protein binding
1.11 4.55e-02 GO:0008270 zinc ion binding
1.07 4.98e-04 GO:0003824 catalytic activity
1.06 1.76e-18 GO:0005488 binding